Spermophilus is a genus of ground squirrels in the squirrel family. As traditionally defined the genus was very species-rich, ranging through Europe, Asia and North America, but this arrangement was found to be paraphyletic to the certainly distinct prairie dogs, marmots, and antelope squirrels. As a consequence, all the former Spermophilus species of North America have been moved to other genera, leaving the European and Asian species as true Spermophilus (the only exceptions are two Asian Urocitellus).

Some species are sometimes called susliks (or sousliks). This name comes from Russian суслик, suslik. In some languages, a derivative of the name is in common usage, for example suseł in Polish. The scientific name of this genus means "seed-lovers" (gr. σπέρμα sperma, genitive σπέρματος spermatos – seed; φίλος philos – friend, lover).